Are you navigating the complex world of BMS CAR-T manufacturing and feeling overwhelmed by your options? You’re not alone! Choosing the right manufacturer can make or break your project, impacting everything from cost to quality. Finding a top supplier means securing cutting-edge technology, reliable production timelines, and expert support—key factors that elevate your CAR-T therapies to the next level. Imagine the peace of mind knowing your product is in the hands of the best in the business.

Ready to streamline your search and discover the leading factories in the industry? Dive into our article and uncover the top BMS CAR-T manufacturing factories that can transform your vision into reality!

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Cell therapy Resources – Bristol Myers Squibb

CD19-directed chimeric antigen receptor (CAR) T cell – BMS Science

Product Details:
CD19 NEX-T (BMS-986353) is an autologous chimeric antigen receptor (CAR) T-cell therapy that targets CD19, a surface antigen on B cells, with a shortened manufacturing process to enhance productivity and CAR T-cell quality.

Technical Parameters:
– Autologous CAR T-cell therapy
– Targets CD19 antigen on B cells
– Shortened manufacturing process
– Increased productivity and quality of CAR T-cells

Application Scenarios:
– Treatment of tumor cells in hematological malignancies
– Potential use in autoimmune diseases such as systemic lupus erythematosus (SLE)
– Rebooting the immune system in autoimmune conditions
– Deep depletion of B cells to reduce autoantibody production

Pros:
– Highly specific targeting of B cells via CD19
– Potential to treat refractory autoimmune diseases
– Rapid and sustained breakdown of B cell-mediated immune response
– Shortened turnaround time for CAR T-cell production

Cell Therapy – BMS Careers

BMS preps for CAR-T growth with $380m Cellares deal

Product Details:
Bristol Myers Squibb (BMS) is preparing for growth in CAR-T therapies through a $380 million deal with Cellares, which focuses on cell therapy manufacturing technology.

Pros:
– Significant investment to enhance CAR-T therapy capabilities.
– Partnership with Cellares to leverage advanced manufacturing technology.

BMS signs $380M deal with cell therapy manufacturer Cellares

Product Details:
Cellares specializes in cell therapy manufacturing, focusing on innovative solutions to enhance the production of cell therapies.

Technical Parameters:
– Advanced automation technology
– Scalable manufacturing processes
– Quality control systems

Application Scenarios:
– Production of CAR-T cell therapies
– Manufacturing of personalized medicine
– Large-scale cell therapy production

Pros:
– Increased efficiency in cell therapy production
– Reduced manufacturing costs
– Enhanced scalability for large patient populations

Cons:
– High initial investment required
– Complexity in technology integration
– Potential regulatory hurdles

BMS gets FDA nod for new CAR-T facility | Pharma Manufacturing

Product Details:
Bristol Myers Squibb’s new CAR-T manufacturing facility in Devens, Massachusetts, approved by the U.S. FDA for commercial production.

Technical Parameters:
– 244,000-square-foot facility
– Supports process development, clinical manufacturing, and commercial
– Part of an 89-acre campus

Application Scenarios:
– Manufacturing of cell therapies for patients with aggressive hematological
– Commercial production of CAR-T therapies such as Breyanzi

Pros:
– State-of-the-art facility designed for advanced cell therapy manufacturing
– Expansion of a global network of FDA-approved manufacturing sites
– Supports transformative therapies for serious medical conditions

What’s the future of cell therapy at BMS? – Bristol Myers Squibb

Product Details:
Cell therapy products aimed at treating cancer.

Technical Parameters:
– Utilizes engineered T cells
– Targets specific cancer antigens
– Personalized treatment options

Application Scenarios:
– Treatment of hematologic malignancies
– Solid tumors
– Relapse prevention in cancer patients

Pros:
– Potential for long-lasting remission
– Personalized approach increases effectiveness
– Minimally invasive compared to traditional therapies

Cons:
– Risk of severe side effects
– High cost of treatment
– Limited availability and accessibility

Transforming cells into cancer fighters – Bristol Myers Squibb

Product Details:
Bristol Myers Squibb offers two approved CAR T cell therapies: Breyanzi (lisocabtagene maraleucel) targeting CD19 for relapsed or refractory large B-cell lymphoma, and Abecma (idecabtagene vicleucel) targeting BCMA as the first CAR T cell therapy for multiple myeloma.

Technical Parameters:
– Breyanzi targets CD19
– Abecma targets BCMA
– Autologous CAR T cell therapy
– NEX T™ manufacturing process for efficiency

Application Scenarios:
– Treatment of relapsed or refractory large B-cell lymphoma
– Treatment of multiple myeloma
– Potential future applications in solid tumors
– Research into allogeneic CAR T cells for faster delivery

Pros:
– Personalized treatment using patient’s own T cells
– Possibility of long-term survival
– Innovative manufacturing processes improve efficiency and quality
– Commitment to addressing unmet medical needs

Cons:
– Complex and personalized manufacturing process
– Current therapies are limited to specific blood cancers
– Potential challenges in scalability and accessibility
– Patient-derived therapies may have variability in response

Our production facility in Leiden – Bristol Myers Squibb

Product Details:
CAR-T cell therapy production services.

Technical Parameters:
– Advanced manufacturing processes
– Quality control measures
– Compliance with regulatory standards

Application Scenarios:
– Treatment of certain types of cancer
– Personalized medicine approaches
– Clinical trials for new therapies

Pros:
– Innovative treatment options for patients
– High level of customization
– Potential for significant therapeutic benefits

Cons:
– Complex manufacturing process
– High cost of production
– Limited availability in some regions

Targeting cancer with CAR T cell therapy – Bristol Myers Squibb

Comparison Table

Frequently Asked Questions (FAQs)

What should I look for in a CAR-T manufacturing factory?
When choosing a CAR-T manufacturing factory, consider their expertise in cell therapy, compliance with regulatory standards, quality assurance processes, and production capacity. It’s also important to evaluate their track record in successful product launches and their ability to scale production as needed.

How can I verify the quality of a CAR-T manufacturer?
To verify quality, check for certifications like ISO and compliance with Good Manufacturing Practices (GMP). Request documentation of their quality control processes and ask for references from previous clients to gauge their reliability and performance.

What are the typical lead times for CAR-T manufacturing?
Lead times can vary significantly based on the complexity of the product and the manufacturer’s capacity. Typically, you can expect lead times to range from a few weeks to several months. Always discuss timelines upfront to align expectations.

How do I ensure the manufacturer can handle regulatory requirements?
Inquire about the manufacturer’s experience with regulatory submissions and approvals. Ask for details on their processes for maintaining compliance with local and international regulations, and whether they have a dedicated regulatory affairs team.

What is the cost structure for CAR-T manufacturing services?
Cost structures can vary widely based on factors like the complexity of the product, volume, and specific services required. Request a detailed quote that outlines all potential costs, including any hidden fees, to help you budget effectively.